Center for Brain Health and Longevity

Supplement Library

Evidence-ranked supplements with at least one human clinical trial. Grades reflect quality and consistency of available evidence, not a personal recommendation. Items marked β˜… Main App also appear in the full Healthspan Portfolio.

Grade: Signal:

Evidence Table

Compare all supplements side-by-side. Click any column header to sort.

Supplement ↕ Grade ↕ Category ↕ Effect Summary Cost/Mo ↕ Risk ↕

My Supplement Stack

Supplements you've selected. Add items from the Browse tab.

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Your stack is empty

Go to the Browse tab and click Add to Stack on any supplement.

πŸƒ Longevity Plan

Select the lifestyle and health interventions you currently practice. Your selections will automatically carry through to the My Risk calculator.

πŸ’‘ How this works: Each intervention shows its estimated dementia / all-cause mortality risk reduction from meta-analyses. Check the ones you already practice β€” your My Risk page will update automatically to show how your plan affects your personal risk estimate.
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✦ = early-stage or animal evidence only  Β·  β„ž = prescription medication  Β·  Percentages are relative risk reductions from observational or RCT meta-analyses; individual results vary.

🧬 Brain Health Plan

Select the cognitive and neuroprotective interventions you currently practice. Selections sync automatically with My Risk.

πŸ’‘ How this works: Check the brain health interventions you currently do. Risk reductions are from dementia-specific meta-analyses (Lancet Commission 2020, etc.). Your My Risk page will reflect these alongside your supplement stack.
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✦ = early-stage or animal evidence only  Β·  β„ž = prescription medication  Β·  Percentages are relative risk reductions from observational or RCT meta-analyses; individual results vary.

⚠ The Hype Zone

Popular supplements that generate significant marketing attention but have little or no credible human evidence, significant safety concerns, or have been warned against by regulatory bodies. Know what to skip β€” or at least approach with serious skepticism.

πŸ’‘ The Opportunity Cost Perspective

Every dollar spent on unproven supplements is a dollar not spent on ones with real evidence. The combined cost of the hype items below ($300–$600/mo) could fund a full evidence-based stack β€” omega-3s, creatine, magnesium, vitamin D, berberine, and more β€” with money left over.

Hype stack: ~$400/mo vs. Evidence-based stack: ~$80–120/mo

🧠 Dementia Risk Profile

Estimate your personal baseline dementia risk, then see how your supplement stack changes absolute β€” not just relative β€” risk.

Your Profile

Low <1 Β· Optimal 1–3 Β· Elevated >3 Β· High >10

Known Risk Factors

πŸƒ Longevity Plan

Check the longevity interventions you currently practice.

🧠 Brain Health Plan

Check the brain health interventions you currently practice.

About this calculator: Baseline 10-year risk uses age-stratified incidence data from the Alzheimer's Association / Brookmeyer et al. Risk factor multipliers are derived from meta-analyses (Livingston et al. 2020 Lancet Commission; Norton et al.). This is an educational estimate only β€” not a clinical tool. Consult your physician for personalised risk assessment.
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Enter your age to see your estimate
Add optional details and risk factors for a more personalised picture.
Disclaimer: This tool is for informational purposes only and does not constitute medical advice. Evidence grades reflect quality of available human trial data, not a personal recommendation. Consult a physician before starting any supplementation regimen. Data current as of March 2026.
Part of the Healthspan Portfolio suite.